Spotlight on Scientific Discovery & Engineering: Cancer Complexity and Cellular Innovation
This JOSHA Spotlight curates five advances that illuminate cancer as a problem of both cellular engineering and clinical decision-making. Mechanistic work in colorectal cancer shows how loss of ATRX disrupts colonic identity, unleashing multilineage plasticity and highly metastatic behaviour. A microfluidic–machine learning platform in breast cancer quantifies how metronomic drug schedules can outperform conventional combinations.…