This editorial curation brings together six timely articles examining how artificial intelligence is reshaping policy, security, privacy, and public trust. It moves from biosecurity risks created by generative protein design to the urgent need for science- and evidence-based AI governance. It also highlights the fragility of consumer genetic privacy, showing how weak legal protections can…
This edition of the Spotlights brings together six curated reads mapping how computation and policy are reshaping medicine: from the pixel to the population. MetaSeg shows how meta-learned implicit neural representations can segment 2D/3D MRI with U-Net–level accuracy using ~90% fewer parameters, pointing to lighter models for routine 3D analysis. In parallel, AI protein-design pipelines…
This Spotlight follows AI as it shifts from a helpful assistant to a system that can produce, judge, and propagate ideas at scale and shows what that change is doing to science, society, and safety. It opens with an “agent-run” conference where AI systems generate papers and other AI systems review them, turning peer review…
Dear josha-journal readers, we welcome all readers to a new issue. JOSHA operates on four key principles: open access, ensuring all articles are freely available to readers worldwide; interdisciplinarity, welcoming submissions from all scientific, artistic, and humanistic disciplines; author copyright retention, allowing authors to keep the rights to their work; and editorial review instead of…
How do systems quietly exhaust the people meant to sustain them? In this JOSHA Spotlight, five pieces map the hidden workload behind healthcare, higher education, and research. It traces antifungal drug resistance from environment to clinic, where agricultural azole use can select resistant fungi and further narrow an already limited treatment toolkit, strengthening the case…
This Spotlight series traces how physics-driven methods and engineering choices are reshaping what we can detect, build, and understand in living systems and how innovation is steered by society. Ultraweak photon emission imaging suggests a label-free window into vitality and stress responses across animals and plants. Ultrasound-enabled in vivo 3D printing extends fabrication beyond the…
Technological systems increasingly shape how people live, love, and relate—often revealing hidden social pressures and vulnerabilities. This Spotlight traces how digital and cultural infrastructures reorganize everyday life: a hyper-competitive housing market that pushes students toward self-marketing and extreme compromises; growing “app fatigue” that drives singles back toward face-to-face dating; and the continued appeal of biography…
The rapid ascent of artificial intelligence reveals a fragmented map of ambition, risk, and hidden labour. While Switzerland cultivates a thriving ecosystem through strategic state–industry partnership, the costs surface elsewhere: chatbots that over-validate vulnerable users can deepen delusional spirals, with real consequences for mental health. At the same time, the race for AI supremacy carries…
JOSHA presents a synthesis of recent research from the Collaborative Research Institute Intelligent Oncology (CRIION), highlighting advances in AI explainability, immune profiling, and cancer therapy resistance. The first study introduces Salvage, a Shapley-distribution–based method that improves interpretability in Vision Transformers through guided sampling. The second explores TRBC1/TRBC2 oligoclonality in T-cell lymphomas, revealing how tumor heterogeneity…
