Spotlight on Cell Biology and Imaging Breakthroughs

This collection reflects JOSHA's editorial curation of recent advances at the intersection of cell biology and imaging technology: Spatial and lineage mapping: Prime editing-based tracing and ultraresolution live imaging are redefining how cell ancestry, chromatin dynamics, and tissue architecture are captured in vivo. Cancer biology and therapy resistance: Distinct FOXA1 mutation classes link chromatin remodeling to divergent prostate cancer trajectories, while microfluidic platforms advance T-cell expansion for immunotherapy applications. Imaging and automation: Deep learning-driven image analysis, from lab-on-chip cell monitoring to morphological profiling of antibiotic-resistant bacteria, is replacing subjective assessment with scalable, objective quantification.