The following article, previously published in the magazine El Gato y La Caja, presents and retracts a problem in the world of today's scientific laboratories. What about experiments? Why don't scientists get the same result twice? The strange case of Dr. Jekyll and Mr. Hyde was born in 1886 and quickly became a classic to the point that, as with most classics, you don't need to have read it to know the story: a renowned scientist discovers a potion that turns him into a perverse and violent subject, dissociating his personality and changing his physical appearance. Between both personalities, there is a tragic battle that knew how to have many reversions in literature and cinema. In the last pages, Dr. Jekyll, with new ingredients, wants to repeat his successful formula. But he does not succeed, because the effect of the potion was due to an impurity in the old inputs, already consumed. This impurity is impossible to trace, which naturally prevents Dr.
Harnessing knowledge AND clinical experience to improve patient care employing an electronic system analyzing non-structured medical records: The “SimRec” Software
The era of digitization reached the medical field. Technological advances and growing access to computer systems drive many health care innovations. In 2009, the United States authorized the Health Information Technology for Economic and Clinical Health (HITECH) Act. It aims to create a 21st-century health care information system. One important step to achieve this goal is the expansion and adoption of electronic health records (Blumenthal 2010). These records consist of different patient characteristics, for example, diagnostic tests, like blood tests as well as social information. Computerized clinical decision support systems (CDSS) use this electronic information to evolve recommendations for the health care staff.
This summer editorial is notable for containing articles of great interest. First, we find a brief summary of what was the night of the Demetrios awards, covering the awards ceremony to its winners for the presentation of research work belonging to different disciplines and also in different languages. Followed by this summary we presented you two publications in the area of medicine and science with topics of high interest, as well as two more articles in the categories of music and society. One of them constitutes the current line of columns published until now by Dr. Hotaki around classical music and the other represents our first article in the form of a report and social criticism, hand in hand with a real testimony
I am a political scientist and in the course of my career as a lecturer and pro-democracy activist, I have traversed over 50 countries across different continents. Hence, I had taken the routine details of international travel for granted – until my traumatic experience in Malaysia where I was detained under extremely dehumanizing conditions for eight days in November 2017. My offense was that I failed to get a transit visa to go from one airport in the country to another. About the Author: Dr. Mike Omilusi is an Independent Democracy Monitor, Freelance Journalist, Development Worker, and University Teacher in Nigeria.
a wonderful evening at the Demetrios Award 2019! The International Academy of Sciences, Humanities, and Arts wants to promote open and interested young scientists and artists and encourage interdisciplinary exchange. To this end, it awards prizes in both categories every year and combines its artistic and scientific concerns at an event. This year, the Demetrios and Pythagoras Prizes were ceremoniously awarded on 6 July 2019 as part of a concert by the Swiss youth big band Swing Kids at the Kurhaus Bad Krozingen.
Unravelling the syndrome of age associated diseases 2: Targeting autoimmunity with anti-CD20 antibodies to reduce age-associated diseases
The antibody Rituximab that was originally used to treat non-Hodgkin's lymphoma or chronic lymphocytic leukemia was found to be effective for all autoimmune diseases studied so far. This raises the question of whether successful treatment of autoimmune reactions, even at the subclinical level, can reduce the risk of cardiovascular disease, cancer, and other age-associated diseases. Animal experiments and initial clinical observations support this novel therapeutic strategy. However, due to the complex biological processes and the long-time required for clinical observations, it is challenging to produce clear evidence from randomized double-blinded studies. It will be crucial to prove in the near future, whether surrogate endpoints (e.g., elimination of autoreactive B cells) can accelerate the development of this strategy. The present preclinical evidence is convincing, but the path from a “promising anti-aging molecule” to “accepted drug” will be long and require further research.
The current issue of the Josha Journal is dominated by the awards ceremony on July 6, 2019. Eight Demetrios Prizes and three Pythagoras Prizes were presented by the International Academy of Sciences, Humanities, and Arts at a successful concert and literature evening. In addition to the prize money, the international prize winners will also be able to publish their qualification papers in the Journal. The theses published in the journal the last weeks are bachelor, master and doctoral theses by young scientists. The spectrum ranges from philosophy and cultural studies to machine learning and medical work. The Pythagoras prizes went to the youth big band "Swing Kids", the poetess Zazie-Charlotte Pfeiffer and the singer Marie Brendle. All of them presented their performances at the award ceremony.
The Psycho-Political Underpinnings of Presidential Speeches: President Buhari’s Three Selected Speeches to Countrymen
Given the fact that presidential persuasion is a central feature of presidential power and leadership, this essay explores the persuasive strategies employed by President Buhari in three selected speeches. Although much research has been done on the rhetoric of presidents at crucial moments in Nigeria, most of these studies focused on international affairs or linguistic appraisal rather than domestic socio-political situations. Interestingly, many of the essays on this subject matter are vagaries from columnists and journalists with seemingly partisan disposition. The thrust of this essay, therefore, is premised on the hypothesis that the three speeches were meant to strike the psychological and political minds of the citizenry during the period under review.
One of the winners, german Julia Pinter, focused his research on the subject of Cancer. Cancer is the disease with the highest mortality worldwide, treated with the same standard approaches for decades. This conventional therapy strategies do not take the evolutionary development of cancer into consideration nor the role of the immune system in this process. Cancer has been shown to hide from the immune surveillance by establishing an immunosuppressive microenvironment. Furthermore, tumor cells are rarely recognized as pathogens by immune cells since they originate from self-material. As a result, there is a recent trend in cancer treatment to redirect the immune system to cancer specificity.
One of the winners, Nicolas Woitzik from Germany, evaluated in his thesis the textual clinical recommender system which represents a computerized clinical decision support system (CDSS). It analyses the patient’s discharge summaries with the help of information retrieval and natural language processing methods. It provides the user with a similar patient case out of a database to include this information into the user's decision-making process. We conducted an experiment to validate the correlation between the computed similarities by the new CDSS and the similarity judgment of medical experts, junior doctors, and medical students. Taken together, the retrieval system still needs improvements, either based on an improved retrieval algorithm or by additional features. However, it is likely that the performance of the system will improve the more discharge summaries a database contains like it was shown in this thesis.