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3697 1817
Published in Volume 2, Issue 1 -

Interferon-stimulated gene expression in chronic hepatitis C virus genotype 1 infected patients treated with the NS3/4A protease inhibitor faldaprevir in combination with pegylated interferon alpha-2a/ribavirin

Yakov Datsenko

Languages: English

DOI: 10.17160/josha.2.1.15

The objective of this study was to investigate the expression of selected interferon-stimulated genes (ISGs) in PBMC (peripheral blood mononuclear cell) prior and during the treatment with NS3/NS4A protease inhibitor faldaprevir plus pegylated interferon alpha-2a/ribavirin (PegIFN/RBV) in treatment-naïve and treatment-experienced chronic hepatitis C virus genotype 1 infected patients. This thesis was performed in three consecutive steps. First, we selected 95 most representative ISGs based on the literature. Secondly, we selected 30 patients for the SVR-oriented exploratory screening and tested all 95 genes in these patients. Finally, we tested 15 genes identified during the SVR-oriented exploratory screening in all patients eligible for this study (N = 263). As a result, we identified 15 genes which may play a role in the treatment response to faldaprevir plus PegIFN/RBV. Five ISGs (IFNA4, DDX58, IRF3, IFI27 and RSAD2) showed association with SVR at various time points.


7860 4794
Published in Volume 2, Issue 1 -

Exercise, concomitant to therapy, has a positive influence on therapy-induced side-effects in patients with haematological malignancies

Fiona Streckmann

Languages: English

DOI: 10.17160/josha.2.1.14

Exercise interventions as a supportive measure in cancer therapy are becoming more and more relevant. With cancer therapy becoming more complex and effective, higher survival rates as well as longer life-spans are being achieved. Consequently, patients’ quality of life is becoming increasingly important and the management of therapy-related side-effects therefore essential. An increasing amount of studies are demonstrating, that the previously propagated rest and immobility during cancer therapy is not only counterproductive but that exercise interventions hold enormous potential regarding the management of side-effects in supportive cancer care and should therefore be taken more seriously. Especially haemato-oncological patients have to cope with many debilitating side-effects due to the disease itself, the long and complex medical therapy as well as the associated immobility.


4014 1772
Published in Volume 1, Issue 1 -

A new Journal - JOSHA

Roland Mertelsmann

Languages: English

DOI: 10.17160/josha.1.1.12

We are happy to publish the first issue 1/2014 of the “Journal of Science, Humanities and Arts – JOSHA”. JOSHA  has been initiated to create a novel internet platform to access the broad diversity of important discoveries and creativity in the fields of Science, Humanities and Arts.


3004 1780
Published in Volume 1, Issue 1 -

Table of Contents for the first issue 1/2014 of the “Journal of Science, Humanities and Arts – JOSHA”

Roland Mertelsmann

Languages: English

DOI: 10.17160/josha.1.1.11

Table of Contents for the first issue 1/2014 of the “Journal of Science, Humanities and Arts – JOSHA”