JOSHA’S CRITICAL REVIEW OF “Efficacy of Larotrectinib in TRK Fusion– Positive Cancers in Adults and Children"
JOSHA´S CONCLUSION. IMPORTANT PROGRESS; ESPECIALLY FOR PATIENTS WITH SARCOMAS FOR WHOM VERY FEW TREATMENT ALTERNATIVES EXIST. TRK-FUSION TESTING SHOULD BECOME ROUTINE IN PATIENTS WITH SARCOMA AND SELECTED PATIENTS WITH OTHER REFRACTORY MALIGNANCIES. JOSHA’S Critical Reviews in Oncology and related areas of medicine and science will focus on recently published clinical and non-clinical studies and discoveries. Our editors feel that there is a strong need for expert opinions on studies and discoveries that may potentially impact on patient care. While any judgment will, of course, be a personal and subjective opinion of our editors with all its limitations, we do hope this service will be helpful for our readers and stimulate thoughts and reflections in face of ever more rapid introductions of new drugs and therapeutic strategies in these days. We do encourage comments by our readers! The photo on the cover: Kinetic art by Carlos Cruz Diez . (re-edited at 12.05.18)
JOSHA’S CRITICAL REVIEW OF “GENE THERAPY IN PATIENTS WITH TRANSFUSION-DEPENDENT β-THALASSEMIA” BY A.A. Thompson et al. N Engl J Med 2018; 378:1479- 1493.
THESE INTERIM RESULTS OF TWO PHASE I/II TRIALS ARE REMARKABLE. THOMPSON AND COLLEAGUES DEMONSTRATE THE PROGRESS OF CLINICAL GENE THERAPY FOR MONOGENETIC DISEASES WITH A MEDIAN OBSERVATION TIME OF 26 MONTHS. WITH A FURTHER REDUCTION IN TRANSPLANT-ASSISTENSIVE CONDITIONING, THIS POTENTIALLY CURATIVE TREATMENT OF BETA-THALASSEMIA MIGHT BECOME STANDARD OF CARE IN THE FUTURE NOT LIMITED TO HIGH-INCOME COUNTRIES. HOWEVER, LONG-TERM FOLLOW -UP DATE ARE STILL NEEDED. JOSHA’S Conclusion: IMPORTANT PROGRESS – MAY BE APPLIED AS STANDARD OF CARE FOR SELECTED PATIENTS. JOSHA’S Critical Reviews in Oncology and related areas of medicine and science will focus on recently published clinical and non-clinical studies and discoveries. Our editors feel that there is a strong need for expert opinions on studies and discoveries that may potentially impact on patient care.
The initiative for organizing this symposium arose a few months ago, during the visit of Prof. Borner and Prof. Mertelsmann. It was supported by the German Consulate of Mendoza, particularly by Mr. Andres Vollmer. Alongwith Mr. Vollmer, the faculty of Medical Sciences and the young researchers showed their excitement about the symposium through their active engagement with its organization. While our Medical School is just sixty-eight years old, it is widely recognized in our country as a public institution with high standards for the education of physicians, nurses and health technicians.
The Editorial board and everybody at JOSHA would like to thank our readers and authors for supporting this wonderful project and for making March and April of 2018 successful for JOSHA. With ten titles including multidisciplinary articles covering interesting aspects of medicine, music, literature and more, including articles from Colombia, Kosovo, Italy, Germany, and Romania. We also started this editorial sharing with pleasure our Demetrios Prize 2018 as a chance for all those who want to have the opportunity to compete for the prizes for Bachelor, Master and PhD Theses and want publish their thesis in Josha Journal. Photo on the cover: Biblioteca de la Real Academia Española.
In this special occasion, we will be celebrating the 10° Anniversary of the IMBS! Scientists and leaders from academic, clinical and research organizations have been invited to share the latest discoveries in biomedicine and public health research aiming to improve the patient's care and health of individuals and the community. This exciting Scientific Program will include some of the latest developments and approaches in specific areas of Cellular & Molecular Biology, Cardiology, Neurology, Oncology Our Congress will also provide a great opportunity for IMBS and Ph.D. students and young scientists to display their work at the poster session where the three most outstanding presentations will be awarded. We look forward to sharing this event with you in Buenos Aires. Application deadline: 30th of June 2018. Admission requirements: Min. Bachelor Degree and at least one year of professional experience in relevant fields and/or in relevant countries.
With this editorial, we are closing the second issue of 2018 with eleven titles including multidisciplinary articles covering interesting aspects of medicine, music, literature and more in 11 articles from Colombian, Kosovo, Italy, Saudi Arabian, Germany, and Romanian. We are proud to end this issue giving our readers the new possibility to write in Arabic. The Editorial board and everybody at JOSHA would like to thank our readers and authors for supporting this wonderful project and for making the first three months of 2018 successful for JOSHA. Photo on the cover: Biblioteca de la Real Academia Española.
The purpose of this paper is to identify and establish an understanding for the importance of Building Rating System (BRS) and insights of a detailed survey of the building’s specifications in compliance literally stated in requirements of Construction Industry Law in Kosovo. BRS will be used as a comprehensive tool to deliver a report to the respective governmental institution and property developer. As an important part of the sustainable construction delivery system, sustainable BRS plays an essential role in implementing the sustainable principles into the construction industry and assessing the building’s rating. The research adopts comprehensive literature reviews from numerous published sources, as journals, government reports, published thesis and website document focusing study on BRS contributions.
This issue has is again very multidisciplinary: medicine, music, socials sciences, children’s books and as our Demetrios project come together to create a very interesting issue. We added new features, a more informative design to allow our readers a more pleasant, productive, and easy access to the contents of JOSHA Journal and Demetrios Books. As a multilingual platform and with the goal of allowing our worldwide readers an easier access to their language of preference, JOSHA included the "Select language to filter search" option. With this new feature, it will be possible to sort all the content in JOSHA by language.
The case that will be analysed is the speech delivered by the political figure Léon Mugesera in November 1992, linked to the Rwandan genocide of 1994. Through his words, it is possible to trace some of the main narratives that primed the ground for the genocide. They are an example of the processes through which a clear enemy, the Tutsi, have been imagined and defined prior to and during the outbreak of 1994 large-scale violence. The first aim of this paper is therefore to understand how modern state-level forces in Rwanda operated to generate narratives that strengthened ethnic affiliations in the eve of the genocide. The second aim is to investigate to what extent the genocidal violence was the product of relentless propaganda, unfounded rumours, prejudices and of collective memory.
The functional concept of TRANSCEND is equally in favor of independent continuation and subsistence of each unit through dedicated projects and financial capital as well as comprehensive projects that fit into place all units of the center for the design of a biomarker with diagnostic value and ultimately linked to the application of a specific and tailored therapy. Pairing Diagnostics with Therapeutics is currently framed under the notion of theranostic. TRANSCEND will promote this convention implying that drugs must be paired with diagnostic biomarkers to enable the right drug to be selected for the right patient at the right time. Central to the integration in such a scheme, which aspire to diagnose, deliver targeted therapy and monitor the response to therapy, is the growth of units of proteomics, bioinformatics and isotopic tracer production for developing a translational biomarker repertoire and a functionally interpretable systems medicine.