JOSHA`s Critical Review of: “Systematic reanalysis of clinical exome data yields additional diagnoses: implications for providers”: IS THERE A NEED FOR “RECALL” IN CLINICAL MEDICINE?
In this study, the importance of new information generated after the initial diagnostic genome analysis was performed is strikingly demonstrated by the fact that new information was of relevance in 10% of the patients in this analysis. While this study focusses on clinical exome analysis, the implications go far beyond this study and potentially apply to all diagnostic and therapeutic procedures performed.
Informing patients of relevant health information and innovations: patient recall or annual physical?
Recently the NEJM published an interesting debate on the value of the annual physical (also known as “periodic health examination”) (Goroll 2015). “Today, because of the rapid growth of medical knowledge and the widening application of technology to medicine, there is a particular need for a continuing authoritative review of, standards for both preventive and therapeutic strategies. Some of these strategies are subsumed under the general category of the periodic health examination.” (Canadian Task Force on the Periodic Health Examination 1979). Although the current debate of the annual physical has narrowly focused on preventive strategies in healthy individuals and building patient-physicians relationship, recent breakthrough clinical innovation in many fields, especially in genomic medicine, widens the need of review to new effective therapy and diagnostics.
The culture of the Kanuri is predominately interesting and attractive. The Kanuri people are very obsessed with their culture which help the quality of cultural traits and vibes high. In Kanuri Culture just as in other ethnic groups throughout the world there are norms and values. Even though most of their culture finds its origin in the Islamic religion, yet they have a couple of traditions that are peculiar to the tribe. One of such traditions is the application of henna, which is not well documented by the social historians and anthropologists. It is based on this assertion that this paper makes attempt to examine the application and importance of Henna among Kanuri people. Henna or “nallê” as the Kanuri call it, is a safe and temporary body art practice for millennia among the Kanuri. The technique employs a paste made from ground leaves of the henna plant (the grand leaves may be mixed with any amount of liquids or oils to create a paste) on the body or skin properly.
With this Editorial, we are closing the 5th issue of 2018. We bring you 10 articles from Countries of all over the world like Venezuela, Kosovo, Norway, Germany, and Argentina. With our first Critical Reviews with a focus on clinically relevant topics, we would like to invite our readers to comment so we can all benefit. We also like to remind our reader of our Demetrios Prize 2018. The manuscripts of the winners will soon be published in the Journal after our award committee has made its selection.
Historically, Kosovo's industry has gone through various stages of its development and fully dependent on the economic system. In general, Kosovo's industrial development was based on the exploitation of raw materials and their processing to a certain degree, but not to a satisfactory degree of processing and finalization. The diversity of industrial building design must always be in line with the requirements of technological processes, economic development, environmental protection and sustainable social development. The study presented in this paper investigated the visual organization of industrial functional compositions, focussing on urban design issues, principles according to the Gestalt laws of grouping, and sustainable urban design.
JOSHA`s CRITICAL REVIEW OF „Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer”
A striking benefit in overall survival was observed, and a less striking benefit in progression-free survival. This is quite in contrast to other recent studies with checkpoint inhibitors demonstrating a significant event-free survival benefit but did not demonstrate an overall survival benefit – as yet. Perhaps disease control without added toxicity is a better strategy than trying to eradicate the last cancer cells with added treatment toxicity? The innovative therapeutic strategies based on concepts of clonal evolution proposed by Cassandra Willyard (Cancer: An evolving threat, Nature 532, 166, 2016) could be of relevance here. Also, the role of type and duration of maintenance therapy should be studied further. JOSHA’S Critical Reviews in Oncology and related areas of medicine and science will focus on recently published clinical and non-clinical studies and discoveries.
ABSTRACT Sustainable Urban Development in Kosovo and Albania is subject to this research paper. Analyzes of spatial planning documents and legislation of Kosova and Albania, toward approaching New Urban Agenda, as benchmarking to sustainable development, its strategic objectives, priorities, modalities is of importance. Kosovo and Albanian cities are facing rapid urbanization due to several developmental and transitional reasons, migration, economic development challenges, initially regulated by spatial planning legislation followed by spatial planning documents. Global trends says that one third of the global population will live in cities by 2050 (UN, 2014), in Albania over two third of population will live in cities after 2035 (UN, World Urbanization Prospects, 2009 Revision). Key words: Sustainable Urban Development, Sustainable Development Goals, Inclusive Human Settlements, Resilient Cities
ABSTRACT The objective to this paper is to identify and evaluate aspects of sustainability by improving energy efficiency of traditional housing in Kosovo. The fact that refurbishment of them is to be more rational, as for sustainable and consistent use of the houses- sustainable occupancy, as for sustainable environmental protection, sustainable tourism, good practice to young urban planners, architects and real estate managers. It is acknowledged that master artisans of traditional architecture in Kosovo were conscious of the sustainability parameters in designing and constructing the traditional houses in villages and rural areas. Efficiency in the use of space, smart building location and orientation, design of the buildings, functionality of inner spaces, lay out of window openings and use of materials have been important for the traditional old buildings.
With this editorial, we are closing the fourth issue of 2018. Lookout for some new updates on our current issue. For instance, the addition of different categories for our multidisciplinary titles likes medicine, music, literature, Visual Arts. We bring you 10 articles from Countries of all over the world like Colombian, Kosovo, Italy, Saudi Arabian, Germany, Argentina, and Romania. We are proud to end this issue with our first critical Reviews about medical topics. We would like to remind our reader about our Demetrios Prize 2018. The manuscripts of the winners will be published in the Journal with a unique DOI for each paper as a chance for all those who want to have the opportunity to publish their research thesis and to win 500 Euros.
Freiburg IMBS "Diploma of Advanced Studies" Winter School in Biomedical Sciences 2018-19 . Now Open for Registration
The Winter School in Biomedical Sciences is a 5 months international program at the University of Freiburg. It is designed as an intensive time of studies and research with specific and practical training that qualifies for success in academia or the private sector. In addition to the modules, students can choose a personal research project. Each research project is individually supervised and involves eight weeks of lab work, that is seven weeks of experimental work followed by a week of data analysis and a written lab report in the format of a scientific research publication.