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Frontiers of Scientific Discovery: Protein Evolution, Spatial Transcriptomics, and Antibody Research
Neher Aseem Parimoo,
Cinthya Souza Simas,
Sara Tóth Martínez,
Gerhard Steinmann,
Roland Mertelsmann
Affiliation: Journal of Science, Humanities, and Arts
Keywords: Scientific Innovation; Spatial Transcriptomics; EVOLVEpro; Antibody; Cell Proliferation.
Categories: News and Views
DOI: 10.17160/josha.12.3.1044
Languages: English
To enhance communication, JOSHA presents a curated selection of articles chosen by its editors. This edition highlights innovative research, including EVOLVEpro, a protein engineering method that integrates protein language models and active learning to optimize enzymes, antibodies, and gene-editing tools; bacterial-MERFISH, a technique for high-resolution bacterial transcriptomics that provides new insights into bacterial behavior and interactions; a reflective piece on the impact of casual academic interactions in overcoming professional hierarchies; and a study on the differential proliferation of plasma cells in antibody affinity maturation, emphasizing the role of IL-21 in promoting high-affinity antibody responses. These studies contribute significantly to advancements in biotechnology, microbiology, and immunology.