Growth hormone (GH) modulation of Epidermal growth factor (EGF) signalling in human mammary epithelial cells

Verena Wölker

Affiliation: Uniklinik Freiburg

Keywords: Breast cancer, growth hormone, epidermal growth factor, ERK, AKT

Categories: Medicine

DOI: 10.17160/josha.2.3.36

Languages: English

This study demonstrates crosstalk between Growth Hormone (GH) and Epidermal Growth Factor (EGF) in two different breast cancer cell lines. Long-term modification of cell viability and the ERK1/2 and AKT pathways was only detected in MDA-231 cells. By simultaneous treatment with GH and EGF, the interaction between GH and EGF in MCF-7 cells could be transiently abrogated by GH-pre-treatment. Co-treatment with GH and EGF diminished cell viability in MCF-7 and MDA-231 cells. Furthermore, a direct influence between GH and EGF signaling resulted in less ERK phosphorylation in MCF-7 cells, whereas in MDA-231 cells less AKT phosphorylation could be observed. EGFR-down regulation due to GH is a potential reason but keeps to be elucidated.

Community Rating: Your Rating:

Leave a comment


There are no comments yet.