Alpha and Omega: from the Sagrada Familia to Placenta and Cancer
Affiliation: GCCC 360 Oncology Genesis Care Corachán, Barcelona, Spain
Keywords: Placental, Immune, Editing, Switches, Foeto-Maternal, Tolerance, Carcinogenesis, Immune Checkpoints, Antoni Gaudi
Categories: Medicine, Visual Arts, Architecture and Design, Humanities, Social Sciences and Law
The links between architecture and science are as old as these human achievements. But modern scientific thought and methods are much more recent than architecture. In 1660, Christopher Wren gave a lecture at one of the regular meetings of the natural philosophers who used to meet at Gresham College in the city of London, and there it was decided to form a society for the promotion of "Physical-Mathematical Experimental Learning". Two years later the Royal Society (now the National Academy of Sciences of the United Kingdom) was born. The Catalan architect Antoni Gaudí was more interested in geometry and God than in scientific research. His obsession with the Alpha and Omega is clearly visible in many of his works. Here we briefly review his impact on his masterpiece in Barcelona, and a certain symbolic conceptual parallelism with the hypothesis that some mechanisms of immunological escape from the placenta (which physiologically lead to Birth) may perhaps be redistributed by cancer cells to avoid immune surveillance (which pathologically leads to Death).