The Dysregulation of the Secretome in the Tumor Microenvironment: A Potential Source for Biomarker Discovery and Personalized Cancer Treatment
The cancer secretome includes all proteins released by cancer cells and the components of the tumor microenvironment. Dysregulation of secretome emerged as a major contributor to cancer initiation and progression. Cancer cells and stromal cells communicate through different secretory pathways and work together to promote tumor growth. Understanding how this tumor-stroma crosstalk drives cancer development…